Lady Gaga is an American singer, songwriter and performance artist. She made her debut in 2008 with her best selling album "The Fame". Matt said in this interview for the Q Awards that his favorite song of the decade was Lady Gaga's "Paparazzi". In the same interview Matt even started singing Paparazzi.
On an interview with Triple J, Matt said "I love her music. I think she's an absolutely superb artist and I love the way she dresses. I really like her".
Also, on an interview with 99.3 The Fox, Muse were asked what artists they'd want to work with musically and Matt answered "Lady Gaga. I'd love to do something with her". .
At the 2010 NME Awards, Matt lost the Worst Dressed Award to Lady Gaga. 
Matt and Dom went to a Lady Gaga concert in Washington D.C. on 29th September,2009 after opening for U2 earlier that same night. Afterwards, he met her backstage. About the meeting, Matt said "The other day, we were opening up for U2 in Washington D.C. We ran offstage quite early because I wanted to go see Lady Gaga play. She was playing in town. I think she's an amazing performer. She wears really cool costumes and stuff. We actually got to meet her as well briefly afterwards. She was all covered in sweat and tight leotards. It was very nice to meet her. I was very excited to meet her actually because I love [Paparazzi] so much. I think it's one of the catchiest songs I've ever heard." On their twitter account, Matt posted a picture of Dom backstage at the concert wearing a Lady Gaga hat.
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